Allergen-Induced Asthma
نویسندگان
چکیده
منابع مشابه
Murine model of allergen induced asthma.
Asthma is a major cause of morbidity and mortality, affecting some 300 million people throughout the world (1). More than 8% of the US population has asthma, with the prevalence increasing (2). As with other diseases, animal models of allergic airway disease greatly facilitate understanding of the underlying pathophysiology, help identify potential therapeutic targets, and allow preclinical tes...
متن کاملAcute allergen-induced airway remodeling in atopic asthma.
Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal trophic unit (EMTU). Endobronchial mucosal biopsies obtained before and 24 h aft...
متن کاملAllergen-induced impairment of bronchoprotective nitric oxide synthesis in asthma.
BACKGROUND Endogenous nitric oxide protects against airway hyperresponsiveness (AHR) to bradykinin in mild asthma, whereas AHR to bradykinin is enhanced by inhaled allergens. OBJECTIVE Hypothesizing that allergen exposure impairs bronchoprotective nitric oxide within the airways, we studied the effect of the inhaled nitric oxide synthase (NOS) inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on ...
متن کاملAsthma: surfactant eliminates the early allergen-induced response
In their recent article BABU et al. [1] have just published a remarkable finding in which they have clearly demonstrated how the inhalation of synthetic surfactant abolishes the early allergen-induced response in asthmatics. In interpreting these impressive results, however, they invoke theory based upon oedema at whose liquid-air interface surfactant could exert a "high surface pressure". In p...
متن کاملEosinophils generate brominating oxidants in allergen-induced asthma.
Eosinophils promote tissue injury and contribute to the pathogenesis of allergen-triggered diseases like asthma, but the chemical basis of damage to eosinophil targets is unknown. We now demonstrate that eosinophil activation in vivo results in oxidative damage of proteins through bromination of tyrosine residues, a heretofore unrecognized pathway for covalent modification of biologic targets i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Respiratory Journal
سال: 2014
ISSN: 1198-2241
DOI: 10.1155/2014/719272